Detection and significance of CXCL8 and IL-10 in serum and tissue of the patients' with OSAHS.
- Author:
Liqiao GE
1
;
Jin HOU
1
;
Jing YAN
1
;
Quanqing KANG
1
Author Information
1. Department of Otorhinolaryngology Head and Neck Surgery, Second Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, 710004, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Case-Control Studies;
Female;
Humans;
Interleukin-10;
blood;
metabolism;
Interleukin-8;
blood;
metabolism;
Male;
Middle Aged;
Sleep Apnea, Obstructive;
blood;
metabolism
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2013;27(15):818-821
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:Detection and significance of CXCL8, IL-10 in serum and tissue of the patients' with OSHAS.
METHOD:All subjects take serum CXCL8 and IL-10 levels were determined by ELISA. All subjects take the same position of the soft palate tissues in the operation. CXCL8 and IL-10 in the tissue expression was measured by immune histochemistry.
RESULT:(1) Serum CXCL8 levels in OSHAS is higher than that in the control group (P < 0.05). (2) Serum IL-10 levels in OSHAS is lower than that in the control group (P < 0.05). (3) Tissues CXCL8 expression was correlated with serum CXCL8 (r = 0.474, P < 0.05). (4) Tissues IL-10 expression wasn't any correlated with serum IL-10. (5) Tissues IL-10 expression was correlated with tissues CXCL8 (r = 0.482, P < 0.05).
CONCLUSION:OSAHS may be a disease associated with inflammation, and closely relate with CXCL8 and IL-10.
