Children's hearing behavior observations and high risk individual genetic screening for late-onset hearing loss early detection and intervention exploring a basic-level hospitals model.
- Author:
Yilian GUO
;
Xiangli ZENG
;
Ting LIU
;
Yudi ZOU
;
Yanchou YE
- Publication Type:Journal Article
- MeSH:
Behavior Observation Techniques;
Child;
Connexin 26;
Connexins;
genetics;
DNA Mutational Analysis;
DNA, Mitochondrial;
genetics;
Deafness;
diagnosis;
genetics;
Early Diagnosis;
Genetic Testing;
Hearing Tests;
Heterozygote;
Humans;
Infant, Newborn;
Male;
Mutation
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2015;29(18):1618-1621
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the methods to detect and intervene children's late-onset hearing loss early which are suitable for basic-level hospitals.
METHOD:Udiology and imaging diagnosis had been given to the children who passed the newborn hearing screening but showed auditory behavior disorders in the growth process, and individualized interventions were given according to the results of diagnosis. Seven children with high risk for hereditary deafness were sent to superior hospital and had molecular screening of common mutations of inherited deafness carried out, then corresponding prevention guidance and intervention were given to them.
RESULT:Fifty-two cases with late-onset hearing loss or verbal disorders were detected by auditory behavior observations,including 4 cases of auditory neuropathy, 4 cases of unilateral sensorineural deafness, 27 cases of secretory otitis media. 13 cases of bilateral sensorineural deafness and 4 cases of autism. Seven newborns with high risk of hereditary deafness were sent to the Third Affiliated Hospital of Sun Yat-Sen University and received molecular screening of common mutations of inherited deafness. One case with GJB2 compound heterozygous mutations was detected and followed up to 4 years old, he was found bilateral moderate hearing loss and accepted the hearing aids at 2 years old. Mitochondrial DNA 1555 a > G heterogeneity mutation in 2 cases and GJB2 235 delC single heterozygous mutations in 3 cases, no mutation in 1 case, all these 6 cases have been followed-up until now, their hearing are normal.
CONCLUSION:Children's auditory behavior observations and the superior hospitals referral performing high risk individual screening for newborns with high risk for hereditary deafness can detect children's late-onset hearing loss in time, this model is suitable for basic-level hospitals.
