Clinical Significance of p53, c-erbB-2, Chromogranin A and PCNA in the Ampullary Carcinoma.
- Author:
Ki Hwan KIM
1
;
Sun Whe KIM
;
Woo Ho KIM
;
Yong Hyun PARK
Author Information
1. Department of Surgery, Seoul National University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Ampullary carcinoma;
p53 protein;
Chromogranin A;
c-erbB-2 gene;
Proliferating cell nuclear antigen
- MeSH:
Chromogranin A*;
Genes, erbB-2;
Humans;
Lymph Nodes;
Neoplasm Metastasis;
Prognosis;
Proliferating Cell Nuclear Antigen*;
Retrospective Studies;
Survival Rate
- From:Journal of the Korean Cancer Association
2001;33(1):84-91
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To determine the clinical significance of p53, c-erbB-2, chromogranin A (CgA), proliferating cell nuclear antigen (PCNA) expression in ampullary carcinoma, a retrospective study was performed. MATERIALS AND METHODS: The cases of 96 patients who underwent curative resection for ampullary carcinoma during the ten-year period (1986-95) were reviewed. And, using paraffin-embedded tumor tissues, immunohistochemical (IHC) staining for p53, c-erbB-2, CgA, and PCNA was performed. RESULTS: The overall five-year survival rate (5-YSR) for these 96 patients was 58%. With regard to TNM stage, the 5-YSR was 71% for stage I (n=36), 62% for stage II (n=29), and 39% for stage III (n=31), respectively. IHC expression rate was 17.6% for c-erbB-2, 19.2% for CgA, and 42.9% for p53. The relative proportion of labelling index of PCNA (<25%, 25-50%, >50%) was 30.8%, 25.3%, and 44.0%, respectively. The PCNA labelling index showedsignificant correlation with tumor size (p=0.032). The PCNA labelling index, c-erbB-2, CgA and p53 were not correlated to extent of invasion, lymph node metastasis, stage, or histologic type. CgA and c-erbB-2 expression and the PCNA labelling index thus had no prognostic value. With regard to p53, the 5-YSR of p53 negative cases was 68.6%; that of p53 positive cases was 47%, with significant difference (p=0.038). CONCLUSION: This result suggests that p53 expression is related to poor prognosis of ampullary carcinoma, and that c-erbB-2 and CgA expression, and the PCNA labelling index, are not significant prognostic factors.
