The response of GABA eliciting the rats outer hair cells during development.
- Author:
Weiwei FENG
;
Jie TANG
- Publication Type:Journal Article
- MeSH:
Animals;
Electrophysiological Phenomena;
Hair Cells, Auditory, Outer;
physiology;
Patch-Clamp Techniques;
Rats;
Receptors, GABA-A;
physiology;
gamma-Aminobutyric Acid;
physiology
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2015;29(22):1999-2002
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:We used electrophysiological methods to study that whether GABA could elicit OHCs outward currents provide evidence for exsitence of GABA-A receptor and investige the relationship between the effect of GABA and the development of OHCs.
METHOD:We used whole-cell recording OHCs at current-clamp or voltage-clamp to verify the function of GABA receptor on OHCs. Then we counteds the responsive cells vs. total number cells, and according to results to study the relationships between the GABA receptor and development of OHCs.
RESULT:OHC was elicited outward current or hyperpolarized by GABA and the responsive cells were decreased with development.
CONCLUSION:The result of GABA receptor decreasing with development suggested that the receptor may draw efferents to OHCs or facilitate the MOC-OHC synapse formation.
