Review of ear and nose and throat involvement in IgG4-RD.
- Author:
Xiaofeng TAO
;
Chang LIU
;
Bo SONG
- Publication Type:Journal Article
- MeSH:
Autoimmune Diseases;
physiopathology;
Ear;
physiopathology;
Fibrosis;
Humans;
Immunoglobulin G;
Nose;
physiopathology;
Pharynx;
physiopathology;
Plasma Cells;
pathology
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2015;29(22):2015-2018
- CountryChina
- Language:Chinese
-
Abstract:
IgG4-related disease (IgG4-RD) is a newly recognized disease entity. IgG4-RD is characterized by a single or multiple masses in one or more organs; a lymphoplasmacytic infiltrate with a high percentage of plasma cells within the lesion staining for IgG4; a peculiar pattern of fibrosis known as "storiform" fibrosis; and elevated serum IgG4 concentrations. IgG4-RD can occur in various organs, including pancreas, kidneys, lungs, retroperitoneum, and prostate gland. The head and neck involvements of IgG4-RD have been chiefly described in Mikulicz disease (MD), Küttner's tumor, orbital? inflammatory pseudotumor, and idiopathic hypertrophic pachymeningitis (IHP) previously. Recent studies reported that IgG4-RD could also involve ear, nose and throat. Here we reviewed the literatures about ear, nose and throat involvement by IgG4-RD, in order to provide some theoretical bases for the diagnosis and treatment of IgG4-RD.
