Expression of hypoxia inducible factor-1alpha and BNIP3 in human laryngeal carcinoma and their relationship.
- Author:
Tao LIU
1
;
Yunpeng BA
Author Information
1. Department of Otorhinolaryngology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou, 450052, China.
- Publication Type:Journal Article
- MeSH:
Carcinoma, Squamous Cell;
metabolism;
pathology;
Female;
Humans;
Hypoxia-Inducible Factor 1, alpha Subunit;
metabolism;
Laryngeal Neoplasms;
metabolism;
pathology;
Male;
Membrane Proteins;
metabolism;
Proto-Oncogene Proteins;
metabolism
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2008;22(3):112-114
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the expression of Hypoxia inducible factor-1alpha (HIF-1alpha)and the Bcl-2/adenovirus E1B 19 kDa-interacting protein 3 (BNIP3) in human laryngeal carcinoma and their relationship.
METHOD:The expression of HIF-1ALPHA and BNIP3 were detected by SP immunohistochemical method in 45 cases with laryngeal carcinoma tissues and 12 adjacent normal laryngeal tissue.
RESULT:The expression of HIF-1alpha and BNIP3 were mainly in cytoplasm and nucleus. Their expression was higher in laryngeal tissue than in adjacent normal laryngeal tissue (P < 0.05). The expression of HIF 1alpha was positively related to that of BNIP3 in laryngeal carcinoma tissues (P < 0.05).
CONCLUSION:The high expression of HIF-1alpha and BNIP3 were closely related in laryngeal carcinomas, both of them played important role in the carcinogenesis and development of laryngeal carcinoma. HIF-1alpha might induce the expression of BNIP3. HIF-1alpha and BNIP3 might to be two potential therapeutic targets in laryngeal squamous, cell carcinomas.
