Expression of Livin in laryngeal squamous cell carcinoma and relationship with bFGF.
- Author:
Xianlu ZHUO
1
;
Houyu ZHAO
;
Zhendong JIANG
;
Qianmei CHEN
;
Aoshuang CHANG
Author Information
1. Department of Otolaryngology, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China. zhuoxianlu@126.com
- Publication Type:Journal Article
- MeSH:
Adaptor Proteins, Signal Transducing;
metabolism;
Adult;
Aged;
Carcinoma, Squamous Cell;
metabolism;
pathology;
Female;
Fibroblast Growth Factor 2;
metabolism;
Humans;
Inhibitor of Apoptosis Proteins;
metabolism;
Laryngeal Neoplasms;
metabolism;
pathology;
Male;
Middle Aged;
Neoplasm Proteins;
metabolism
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2008;22(3):114-116
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To detect the roles of Livin and its relationship with bFGF in laryngeal squamous cell carcinoma (LSCC) through observing the expression of Livin and bFGF in laryngeal squamous cell carcinoma.
METHOD:Expression of Livin and bFGF in 41 cases of LSCC (11 cases with lymph node metastasis) and 20 cases of normal soft palate mucosa were detected by immunohistochemistry.
RESULT:Livin were positively detected in 29 (70.73%) cases of LSCC and negatively detected in all normal soft palate tissue. The positive rate of Livin was higher in LSCC than that in normal soft palate tissue and the expressions were significantly associated with lymph node metastasis status (P < 0.05) but not with histological grade, clinical stage and age (P > 0.05). The expression of Livin was positively correlated with the expression of bFGF.
CONCLUSION:The elevated expression of Livin in LSCC might play an important role in the development of laryngeal squamous cell carcinoma and bFGF might be involved in the process.
