Expression of Survivin, Caspase-3 and p53 in surgical margin of laryngeal squamous cell carcinoma and their relationship.
- Author:
Jinduo DU
1
;
Xiaofang SUN
;
Congzhe TIAN
;
Xian GENG
;
Yajing SU
Author Information
1. Department of Otolaryngology, Affiliated Hospital of Hebei University, Baoding, 071000, China. djdlly@yahoo.com.cn
- Publication Type:Journal Article
- MeSH:
Aged;
Carcinoma, Squamous Cell;
metabolism;
pathology;
surgery;
Caspase 3;
metabolism;
Female;
Humans;
Inhibitor of Apoptosis Proteins;
metabolism;
Laryngeal Neoplasms;
metabolism;
pathology;
surgery;
Male;
Middle Aged;
Neoplasm Recurrence, Local;
Prognosis;
Survivin;
Tumor Suppressor Protein p53;
metabolism
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2008;22(3):117-121
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the expression of Survivin, Caspase-3 and p53 in surgical margin of laryngeal squamous cell carcinoma (LSCC), and their clinical significance and relationship.
METHOD:Immunohistochemistry method was used to detect the expression of Survivin, Caspase-3 and p53 in 116 cases of surgical margin of LSCC.
RESULT:According to the recurrence, the patients were divided into four group, recurrence within one year, between one year to three years, between three to five years, more than 5 years (include no recurrence). The expression rate of survivin were 92.9%, 85.0%, 50.0% and 21.1% (P < 0.01) in four groups, respectively. The expression rate of Caspase-3 were 50.0%, 50.0%, 66.7% and 89.5% (P < 0.01). The expression rate of p53 were 57.1%, 37.5%, 45.8% and 18.4% (P < 0.05). The expression rate of survivin, caspase-3 and p53 in four groups, respectively, there were significant differences (P < 0.05).
CONCLUSION:Expression of Survivin, Caspase-3 and p53 in surgical margin of LSCC may play an important role in the tumorigenesis and development of laryngeal carcinoma. They are feasible for early diagnosis and prognosis estimation.
