Expression and clinical significance of breast cancer metastasis suppressor 1 mRNA in supraglottic laryngeal carcinoma.
- Author:
Xiaoyu LI
1
;
Xing GUO
;
Fucai LI
;
Xiaotian LI
;
Chao GUAN
;
Huaian YANG
;
Zimin PAN
;
Chanyuanz LI
;
Zhong REN
Author Information
1. Department of Otorhinolaryngology, First Clinical College, Chinese Medical University, Shenyang, 110001, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Carcinoma, Squamous Cell;
metabolism;
pathology;
Female;
Humans;
Laryngeal Mucosa;
metabolism;
pathology;
Laryngeal Neoplasms;
metabolism;
pathology;
Lymphatic Metastasis;
Male;
Middle Aged;
Neoplasm Proteins;
metabolism;
RNA, Messenger;
genetics;
Repressor Proteins
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2008;22(6):241-244
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the expression of breast cancer metastasis suppressor 1 (BRMS1) mRNA in supraglottic cancer and to evaluate its clinical significance.
METHOD:The expression of BRMS1 mRNA was examined by using RT-PCR method which take beta-actin mRNA as reference template in 66 cases of supraglottic cancer tissues and their adjacent normal mucosa tissues (ANT).
RESULT:The expression of BRMS1 mRNA in the tissues of supraglottic cancer is lower significantly than that in the tissues of ANT ( P<0.05). There is correlation between BRMS1 mRNA expression and the clinical stage, differentiation and cervical lymph node metastasis in the laryngeal supraglottic cancers (P<0.05). There is no correlation between BRMS1 mRNA expression and sex and age.
CONCLUSION:Expression of BRMS1 mRNA in supraglottic cancer is lower than that in adjacent normal mucosa. The decrease of BRMS1 mRNA expression may be related to clinical stage and low differentiation and lymph node metastasis of supraglottic laryngeal cancer.
