The clinical significance of the expression of costimulatory molecule PD-L1 in nasopharyngeal carcinoma.
- Author:
Feng ZHANG
1
;
Zheng LIU
;
Yonghua CUI
;
Guohua WANG
;
Ping CAO
Author Information
1. Department of Otorhinolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. lhkzhangfeng@163.com
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Antigens, CD;
metabolism;
Apoptosis;
B7-H1 Antigen;
Female;
Humans;
Male;
Middle Aged;
Nasopharyngeal Neoplasms;
immunology;
metabolism;
pathology;
Tumor Escape
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2008;22(9):408-410
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the expression of ligand 1 of programmed death-1 in human nasopharyngeal carcinoma (NPC), the relationship between their expression and the clinicopathological features.
METHOD:Immunohistochemistry was performed to assess the expression of PD-L1 in 59 cases of NPC tissues and 10 cases of normal nasopharyngeal tissue. RT-PCR was used to investigate the mRNA expression of PD-L1 gene in 30 NPC samples and 10 cases of normal nasopharyngeal tissues.
RESULT:In case of tissues of nasopharyngeal carcinoma, the positive expression rate of PD-L1 protein and PD-L1mRNA were 67.8% (40/59) and 66.6% (20/30) respectively, while there were no PD-L1 detectable in normal nasopharyngeal tissues. The expression of PD-L1 was significantly correlated with clinical TNM stage and lymphatic metastasis (P <0.05). However, no significant correlation was founded between the expression of PD-L1 and age and sex (P >0.05).
CONCLUSION:PD-L1 is overexpressed in nasopharyngeal carcinoma, PD-L1 maybe play a certain role in carcinogenesis and progression of nasopharyngeal carcinoma and turn into a new target of immunotherapy of nasopharyngeal carcinoma.
