Expression and clinical significance of E-cadherin and beta-catenin proteins in human laryngeal cancer.
- Author:
Wei Feng SI
1
;
Wenha SUN
;
Huamin LIU
;
Jie LIU
;
Yan SUN
;
Zhijun CHEN
Author Information
1. Department of Otorhinolaryngology, Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Cadherins;
metabolism;
Carcinoma, Squamous Cell;
metabolism;
pathology;
Female;
Humans;
Laryngeal Neoplasms;
metabolism;
pathology;
Lymphatic Metastasis;
Male;
Middle Aged;
Neoplasm Staging;
beta Catenin;
metabolism
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2008;22(10):459-461
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the roles of E-cadherin and beta-catenin play in the carcinogenesis and progression of laryngeal carcinoma.
METHOD:Immunohistochemistry staining (PicTure two steps method) was used to detect E-cadherin and beta-catenin proteins expression in laryngeal carcinomas and normal epithelia around tumors.
RESULT:In 60 laryngeal carcinomas, the abnormal expression rates of E-cadherin and beta-catenin were 55.00% and 66.67% respectively. The significant relationship was observed between abnormal E-cadherin and beta-catenin expression and differentiation, clinical stage and lymph node metastasis. There was a positive relationship between the expression of beta-catenin and E-cadherin in same sample.
CONCLUSION:The abnormal expression of E-cadherin and beta-catenin were closely related with differentiation, clinical stage, metastasis in laryngeal carcinoma.
