Expression and significance of integrin beta1 and integrin-linked kinase in laryngeal carcinoma.
- Author:
Yuxiao DU
1
;
Chengzhang YANG
;
Xiaomeng ZHANG
;
Long ZHANG
Author Information
1. Department of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Carcinoma, Squamous Cell;
metabolism;
pathology;
Female;
Humans;
Integrin beta1;
metabolism;
Laryngeal Neoplasms;
metabolism;
pathology;
Lymph Nodes;
pathology;
Male;
Middle Aged;
Neoplasm Staging;
Protein-Serine-Threonine Kinases;
metabolism
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2008;22(11):500-503
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the expressions and clinical significance of integrin beta1 and integrin-linked kinase(ILK) in laryngeal carcinoma (LSCC).
METHOD:The mRNA and protein levels of integrinbeta1 and integrin-linked kinase in 43 specimens of laryngeal carcinoma, its surrounding tissue and 18 specimens of vocal cord polyp were detected by reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry SABC method.
RESULT:The mRNA levels of integrin beta1 and ILK protein were significantly higher in laryngeal carcinoma than that in its surrounding tissue and vocal cord polyp (P < 0.05). There was significant correlation between the levels of integrin beta1 expression and the status of cervical lymph node, either between the level of ILK expression and cervical lymph node status (P < 0.05). There was significant correlation between the levels of integrin beta1 expression and T-category, either between the level of ILK expression and T-category (P < 0.05). But pathological grades was not significantly related with the level of integrin beta1 or ILK expression (P > 0.05).
CONCLUSION:The expressions of integrin beta1 and ILK are increased in LSCC. Integrin beta1 and ILK may contribute significantly to invasion and metastasis of LSCC.
