Effect of jieminqufeng decoction on cyclic nucleotides from the rats of allergic rhinitis.
- Author:
Yongjiu HUANG
1
;
Zhaoxin MA
;
Ping HUANG
;
Ming LI
;
Xingwei KUANG
;
Xuhui KONG
;
Xueli BAO
Author Information
1. Department of Otolaryngology-Head and Neck Surgery, People's Hospital of Taizhou, Taizhou 225300, China. huangyongjiu99@yahoo.com.cn
- Publication Type:Journal Article
- MeSH:
Animals;
Anti-Inflammatory Agents;
therapeutic use;
Cyclic AMP;
analysis;
Cyclic GMP;
analysis;
Drugs, Chinese Herbal;
therapeutic use;
Male;
Phytotherapy;
Rats;
Rats, Wistar;
Rhinitis, Allergic, Perennial;
drug therapy
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2008;22(11):513-515
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the curative effect of Jieminqufeng decoction to the rats of allergic rhinitis and study the mechanism by which it treats allergic rhinitis.
METHOD:Forty wistar rats were divided into 4 groups at random. There are Jieminqufeng decoction group, cetirizine group, model control group and normal control group. The rats of allergic rhinitis were established with ovalbumin. We surveyed the behavioral changes of rats, searched eosinophilic granulocytes in the nasal secretion, detected the contents of cAMP and cGMP in the blood plasma and nasal mucosa.
RESULT:The model control group had typical symptoms of allergic rhinitis and the eosinophilic granulocytes could be found more frequently. The contents of cAMP and cAMP/cGMP rose in the blood plasma and nasal mucosa (P < 0.01). However, the changes of jieminqufeng decoction group were small.
CONCLUSION:The jieminqufeng decoction is an effective drug to allergic rhinitis. Its possible mechanism is that it changes the contents of cAMP and cGMP, lessens inflammatory reaction and blocks up the allergy.
