The effect of short-time continuous positive airway pressure treatment on insulin sensitivity in patients with obstructive sleep apnea-hypopnea syndrome and type 2 diabetes.
- Author:
Hongmei WANG
1
;
Lin WANG
;
Jixiang LIU
Author Information
1. The Post-graduate Department, the Tianjin Medical University, Tianjin, 300070, China.
- Publication Type:Journal Article
- MeSH:
Aged;
Continuous Positive Airway Pressure;
Diabetes Mellitus, Type 2;
complications;
therapy;
Female;
Humans;
Insulin;
pharmacology;
Insulin Resistance;
Male;
Middle Aged;
Sleep Apnea, Obstructive;
complications;
therapy
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2008;22(13):597-599
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effects of short-time continuous positive airway pressure treatment before the surgery on insulin sensitivity in patients with obstructive sleep apnea-hypopnea syndrome and type 2 diabetes who need the operation of uvulopalatopharyngoplasty.
METHOD:Thirty cases of patients with moderate and severe obstructive sleep apnea-hypopnea syndrome and type 2 diabetes who need the operation of UPPP were included in this study. The apnea hypopnea index (AHI) and LSaO2 and the insulin sensitivity index (ISI) was evaluated by homeostasis model assessment (HOMA), after 7 days of effective CPAP treatment. Subsequently, the data of the PSG and the ISI were rechecked and compared to the data previously achieved.
RESULT:After 7 days of effective CPAP treatment, the level of AHI and LSaO2 changed (P < 0.05). The level of ISI improved (P < 0.05), while the level of AHI was correlated with fasting blood insulin level (r = 0.6365, P < 0.05) and was inverse correlated with insulin sensitivity (r = - 0.6229, P < 0.05). There was an negative correlation between LSaO2 and fasting blood insulin level (r = -0.8889, P < 0.05), and there was a correlation between LSaO2 and insulin sensitivity (r = 0.9526, P < 0.05).
CONCLUSION:The 7 days of effective CPAP treatment could improve the hypoxia of patients, and it could enhance the ISI and could reduce the operation risk of UPPP.
