A rat model for cochlear implant research.
- Author:
Wei LU
1
;
Jin XU
;
R K SHEPHERD
Author Information
1. Department of Otolaryngology, 1st Affiliated Hospital, Zhengzhou University, Zhengzhou, 450052, China. luweimd@hotmail.com
- Publication Type:Journal Article
- MeSH:
Animals;
Cochlear Implantation;
methods;
Cochlear Implants;
Evoked Potentials, Auditory, Brain Stem;
Male;
Models, Animal;
Rats;
Rats, Wistar
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2008;22(13):603-605
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To introduce a rat model for use in cochlear implant related research.
METHOD:Five deafened Hooded-Wistar rats were implanted with a scala tympani electrode array using a new surgical method. Electrically evoked brainstem responses (EABRs) using bipolar stimulation were recorded and cochlear history was assessed.
RESULT:Electrically evoked brainstem responses with normal configuration confirmed the functional status of the cochlear implantation. There was no evidence of severe insertion-induced damage of intra-cochlear structure.
CONCLUSION:The surgical method established in the rat model is a safe and effective procedure for acute or chronic cochlear implantation.
