Expression and clinical significance of cyclooxygenase-2 in nasal and paranasal sinus carcinoma.
- Author:
Dewei CUI
1
;
Fuquan XIE
;
Xiangbao ZHANG
Author Information
1. Department of Otolaryngology, the Affiliated Hospital of Guangdong Medical College, Zhanjiang, 524001, China. cuidewei@163.com
- Publication Type:Journal Article
- MeSH:
Aged;
Cyclooxygenase 2;
metabolism;
Female;
Humans;
Male;
Middle Aged;
Nasal Cavity;
pathology;
Neoplasm Staging;
Nose Neoplasms;
metabolism;
pathology;
Paranasal Sinus Neoplasms;
metabolism;
pathology
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2008;22(14):629-631
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the relationship between the expression of cyclooxygenase-2 (COX-2) and the carcinogenesis and invasive behavior of nasal and paranasal sinus carcinoma (NPSC).
METHOD:The expression of COX-2 were detected in 69 case NPSC tissues, paracancerous atypical hyperplasia tissue and normal tissue by using immunohistochemical techniques of SP method.
RESULT:The positive rate of COX-2 in NPSC tissues and atypical hyperplasia tissue and normal tissue was 65.22% and 42.31% and 3.33%, respectively. The positive rate of COX-2 in NPSC tissues was significantly higher than that in normal tissue (P < 0.01), and increased apparently with the lesion progressing from normal to atypical hyperplasia tissue to NPSC tissues, and also correlated with the increasing of tumor (P < 0.05).
CONCLUSION:COX-2 may play an important role in the carcinogenesis and invasion of NPSC.
