Expression of Heparansulfate Interacting Protein (HIP) in benign prostatic hyperplasia,prostate intraepithelial neoplasia and prostate cancer
- Author:
Ngoc Thi Phuong Nguyen
;
Thuy Thu Nguyen
;
Chi Kim Dao
;
Khanh Van Tran
;
Van Thanh Ta
- Publication Type:Journal Article
- Keywords:
HIP expression;
Prostate cancer;
Prostatic hyperplasia.
- MeSH:
HIP expression;
Prostate cancer;
Prostatic hyperplasia.
- From:Journal of Medical Research
2008;56(4):98-104
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Background: Heparansulfate Interacting Protein (HIP) is up-regulated in various human cancer cell lines at both transcript and protein levels. HIP expression is related to the differentiation status and cancer development. Objectives: To determine HIP in benign prostatic hyperplasia, prostatic intraepithelial neoplasia and prostate cancer tissues. Materials and method: Western blot method was used to determine HIP expression in 3 different types of prostate tissue, including 11 prostate cancer samples, 2 benign prostatic hyperplasia samples and 11 prostatic intraepithelial neoplasia samples. Results. HIP was particularly up-regulated in prostate cancer and prostatic intraepithelial neoplasia, indicating that up-regulation of HIP expression may be an early event in tumorgenesis. Conclusion: The expression of HIP was different between cancer, prostatic intraepithelial neoplasia tissue and benign prostatic hyperplasia. HIP may serve as a prognostic marker for prostate carcinoma.
