The effect of 18β-glycyrrhetinic acid on tight junctions of the nasal mucosa epithelial cells in rat models with allergic rhinitis.
- Author:
Yi MA
;
Yan GUI
;
Youhu WANG
;
Kehu XI
;
Xiaowan CHEN
;
Fuhong ZHANG
;
Chunxia MA
;
Hao HONG
;
Xiangyi LIU
;
Ying JIANG
;
Ming DONG
;
Guijun YANG
;
Xiaobing ZHANG
- Publication Type:Journal Article
- MeSH:
Animals;
Cell Count;
Epithelial Cells;
ultrastructure;
Glycyrrhetinic Acid;
analogs & derivatives;
pharmacology;
Nasal Mucosa;
cytology;
Ovalbumin;
Rats;
Rats, Wistar;
Rhinitis, Allergic;
drug therapy;
Tight Junctions;
drug effects
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2014;28(20):1590-1594
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe 18β-glycyrrhetinic acid (GA) impact on ultrastructure of tight junctions (TJs) of nasal mucosa epithelial cells in rats models of allergic rhinitis (AR).
METHOD:Ninety-six Wistar rats were randomly divided into control group, model group, loratadine group, and 18β-glycyrrhetinic acid group, and each group had 24 rats. Ovalbumin was used to establish a rat AR model. The behavioral changes and the tight junctions of nasal epithelial were observed and compared in different groups after 2,4,6 and 10 weeks intervention.
RESULT:The length of TJs in allergic rhinitis model became shorter, electron-high-density plasma membrane became thicker, number of the integration loci reduced and gap of TJs widened or even ruptured. With the consistent effect of allergens,the changes of TJs in the model group aggravated gradually,and the changes of ultrastructure of TJs in 18β-glycyrrhetinic acid group was relieved apparently compared to model group and even were close to the control model with time.
CONCLUSION:18β-glycyrrhetinic acid can recover the ultrastructure of the tight junctions of AR rat nasal epithelial cells.
