Study on the function and mechanism of Th17/Treg imbalance on mucosal remodeling of ECRSwNP.
- Author:
Dawei WU
;
Qian SONG
;
Jianting WANG
- Publication Type:Journal Article
- MeSH:
Chronic Disease;
Humans;
Nasal Mucosa;
Nasal Polyps;
metabolism;
Rhinitis;
metabolism;
Sinusitis;
metabolism;
T-Lymphocytes, Regulatory;
Th17 Cells
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2014;28(20):1628-1632
- CountryChina
- Language:Chinese
-
Abstract:
Chronic rhinosinusitis (CRS) can be controlled by a combination of conservative treatment and surgical procedures. However, there is one group of CRS endotypes, refractory CRS, such as eosinophilic chronic rhinosinusitis with nasal polyp (ECRSwNP), for which the current treatment strategies of anti-inflammatory and/or antibiotic therapy or surgical removal of the lesion to improve sinus drainage are less effective. This lack of treatment efficacy highlights the need for further fundamental and clinical research to improve or restore nasal mucosal function of CRS. The role of the immune response in the pathogenesis of mucosal remodeling, which is a key problem in refractory CRS, is of particular current interest. ECRSwNP characterized by Th17/Treg imbalance in- duced by IL-6 has a different mucosal remodeling pattern. This review intends to illustrate the role of the imbalance between Th17 (T helper 17) and Treg (regulatory T) cells in the mucosal remodeling of ECRSwNP and to suggest a novel therapeutic target on treating ECRSwNP.
