Analysis of Clinical Features and Prognostic Factors of Ocular Surface Squamous Neoplasia.
10.3341/jkos.2014.55.4.506
- Author:
Hyun Ho JUNG
1
;
Jee Myung YANG
;
Kyung Chul YOON
Author Information
1. Department of Ophthalmology, Chonnam National University Medical School, Gwangju, Korea. kcyoon@jnu.ac.kr
- Publication Type:Original Article
- Keywords:
Mitomycin C;
Ocular surface squamous neoplasia
- MeSH:
Biopsy;
Conjunctiva;
Cornea;
Diagnosis;
Foreign Bodies;
Gelatin;
Humans;
Mitomycin;
Recurrence;
Retrospective Studies;
Sensation
- From:Journal of the Korean Ophthalmological Society
2014;55(4):506-512
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To analyze the clinical features and prognostic factors of ocular surface squamous neoplasia (OSSN). METHODS: A total of 31 eyes of 31 patients with suspected OSSN who were treated with excision and biopsy were retrospectively reviewed. Clinical features such as patient symptoms, invasion type, morphologic feature and size of lesion were analyzed. All patients were treated with simple excision or mitomycin C combination therapy. Factors affecting recurrence were evaluated. RESULTS: The most common symptom, invasion type, morphological feature, lesion size and histological diagnosis were foreign body sensation (38.7%), combined conjunctiva and cornea type (71.0%), gelatinous type (74.2%), 5 - 10 mm in largest diameter (45.2%) and intraepithelial neoplasia (51.6%), respectively. Age, sex, morphological features, lesion size and histological diagnosis had no effect on recurrence. Mitomycin C combination therapy was significantly associated with decreased recurrence compared to simple excision (p < 0.05). CONCLUSIONS: In OSSN, intraepithelial neoplasia was the most common subtype. Mitomycin C combination therapy was effective in decreasing recurrence.
