Expression and significance of Eotaxin and Eotaxin-2 in nasal polyposis and nasal polyp tissue.
- Author:
Yuqin DENG
1
;
Zezhang TAO
;
Jinhui CHEN
;
Bokui XIAO
;
Yonggang KONG
;
Yuzhen WU
Author Information
1. Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Chemokine CCL11;
metabolism;
Chemokine CCL24;
metabolism;
Child;
Female;
Humans;
Male;
Middle Aged;
Nasal Polyps;
metabolism;
pathology;
Young Adult
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2007;21(2):75-78
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the expression of Eotaxin and Eotaxin-2 in nasal polyposis and nasal polyp and explore the different mechanism between polyposis and polyp.
METHOD:Fifteen cases of nasal polyposis, thirteen cases of polyp and eight cases of normal middle turbinate were studied with immunohistochemical SP method to detect the expression of Eotaxin and Eotaxin-2.
RESULT:There were significant differences between either two groups about the expression of Eotaxin-2 (P < 0.05). The expression of Eotaxin in nasal polyposis and polyp were dramatically higher than in controls (P < 0.05), the expression of Eotaxin between nasal polyposis and polyp was no remarkable difference (P > 0.05).
CONCLUSION:Both of Eotaxin and Eotaxin-2 likely play key roles in the inflammatory reaction process of nasal polyposis and polyp. The different expression of Eotaxin-2 between nasal polyposis and polyp demonstrates it may be one of the main causes in the different mechanism of the two diseases.
