Erythromycin effects on apoptosis of epithelial cell in nasal polyps.
- Author:
Lei YANG
1
;
Sainan XU
;
Yongguo JIN
Author Information
1. Biotechique Center of Wenzhou Medical College, Wenzhou, 325000, China. yeleye@sohu.com
- Publication Type:Journal Article
- MeSH:
Apoptosis;
drug effects;
Epithelial Cells;
drug effects;
Erythromycin;
pharmacology;
Humans;
Nasal Polyps;
pathology
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2007;21(2):84-85
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the effect of erythromycin on apoptosis in epithelial cell and investigate the significance of epithelial cell apoptosis in nasal polyps forming.
METHOD:Epithelial cell collected from thirty nasal polyps and six inferior turbinates were cultured in Dulbecco Eagle and Ham F12 (1:1) and divided into two groups, one cultured with Erythromycin(Erythromycin group), another cultured without Erythromycin (control group). Apoptosis was detected by terminal deoxynucleotidyl transferase mediated dUTP nick end labeling.
RESULT:The AI (apoptosis index) of epithelial cell in nasal polyps after cultured for 1,3,5 days with erythromycin were respectively (33.23 +/- 6.50)%, (38.21 +/- 7.22)% and (52.63 +/- 7.86)%. The AI of epithelial cell in inferior turbinates were respectively (31.02 +/- 5.60)%, (32.13 +/- 7.15)% and (39.64 +/- 7.48)%. There were significant difference between two groups at 5 day after culture (P < 0.05).
CONCLUSION:Erythromycin promoted apoptosis of epithelial cell in nasal polyps.
