Expression of connective tissue growth factor (CTGF), osteopontin (OPN) and clinical significances in the laryngeal squamous cell carcinoma tissues.
- Author:
Youzhong LI
1
;
Yongde LU
;
Yici CENG
;
Xinming YANG
Author Information
1. Department of Otorhinolaryngology, the Xiangya Second Hospital of Central South University, Changsha, China. Liyouzhong1963@yahoo.com.cn
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Carcinoma, Squamous Cell;
metabolism;
pathology;
Connective Tissue Growth Factor;
metabolism;
Humans;
Laryngeal Neoplasms;
metabolism;
pathology;
Male;
Middle Aged;
Osteopontin;
metabolism
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2007;21(3):121-123
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the expressions of CTGF and OPN and detect their clinical value and correlation in the laryngeal squamous cell carcinoma tissues and paracancerous tissues.
METHOD:SP immunohistochemical method was used for the assays of CTGF and OPN on the routinely paraffin-embedded sections of surgical operated specimens of 41 cases with laryngeal squamous cell carcinoma and 20 ones with paracancerous tissues.
RESULT:The positive rate of CTGF and the score were significantly lower in cancer tissues than those in paracancerous tissues (61.0% vs 90.0%, P < 0.05; 2.41 +/- 1.60 vs 4.24 +/- 1.42, P < 0.01), but those of OPN were opposite (61.0% vs 15.0%, P < 0.01; 3. 10 +/- 1.63 vs 1.12 +/- 0.84, P < 0.01). The positive rates and scores of CTGF were significantly higher in the cases without-metastasis of lymph node and clinical stage T1 than those in the ones with-metastasis of lymph node and clinical stage T3 (P < 0.01) . The positive rates and scores of OPN were significantly lower in the cases without-metastasis of lymph node, clinical stage T1 and histological grade I those that in the ones with-metastasis of lymph node, Clinical stage T3 and histological grade III (P < 0.01). The closely negative correlation was found between the score of CTGF and that of OPN.
CONCLUSION:The expression of CTGF and/or OPN might be important biological markers in reflecting the progression, biological behaviors, metastatic potential and prognosis of the laryngeal squamous cell carcinoma.
