The effects of small dose of intratympanic gentamicin injection on intractable Meniere's disease.
- Author:
Chunfu DAI
1
;
Guoming ZHANG
;
Ru ZHANG
;
Jianping LIU
;
Fanglu CHI
;
Zhengmin WANG
Author Information
1. Department of Otology and Skull Base Surgery, Eye Ear Nose Throat Hospital, Fudan University, Shanghai, China. cfdai66@yahoo.com.cn
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Ear, Middle;
Female;
Gentamicins;
administration & dosage;
therapeutic use;
Humans;
Male;
Meniere Disease;
complications;
drug therapy;
Middle Aged;
Retrospective Studies;
Vertigo;
drug therapy;
etiology;
Young Adult
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2007;21(4):151-153
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the efficacy of small dose of intratympanic gentamicin injection on intractable Meniere's disease.
METHOD:Retrospectively study the efficacy of gentamicin intratympanic injection on intractable Meniere's disease. The end-point of treatment was determined based on bedside tests (Spontaneous Nystagmus test, Head shaking test and Head Thrust test), hearing tests, or the improvement of patients symptoms.
RESULT:Nineteen patients with Meniere's disease were treated with intratympanic gentamicin injection. Vertigo control was achieved in 17 patients (89%). Of them, vertigo of 5 patients was successfully controlled after single injection. Eight patients need double injections and 4 patients need the third injections to control the vertigo. Endolymphatic sac shunt was performed to 1 patient because he could not tolerate the fullness of ear due to injection. The remainder 2 patients with double injections showed no improvement of vertigo and rejected further treatment. Hearing was improved in two patients after gentamicin injection. Three patients complained of hearing loss after intratympanic gentamicin injection. The hearing of the other patients did not change.
CONCLUSION:Three weeks after using small dose of gentamicin intratympanic injection to treat intractable Meniere's disease, it was determined whether more injections is required. The results showed that by using this approach, the vertigo could be effectively controlled and the risk of hearing loss following intratympanic gentamicin injection could be reduced.
