The value of cyclooxygenase-2 to predict the effect of radiotherapy in nasopharyngeal carcinoma.
- Author:
Yangyun LIU
1
;
Suping ZHAO
;
Gengxun LIU
;
Zhengxian LI
;
Zhengliang SUN
;
Wen JIANG
Author Information
1. Department of Otolaryngology, the No. 163 Hospital of PLA, Changsha, 410003, China. lyyundr@yahoo.com.cn
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Cyclooxygenase 2;
metabolism;
Female;
Humans;
Male;
Middle Aged;
Nasopharyngeal Neoplasms;
metabolism;
pathology;
radiotherapy;
Neoplasm Staging;
Predictive Value of Tests;
Prognosis;
Sensitivity and Specificity;
Young Adult
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2007;21(5):199-202
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the relation between the expression of COX-2 protein and the effect of radiotherapy, estimate the value of COX-2 in predicting the effect of radiotherapy in patients with nasopharyngeal carcinoma,provide theoretical basement for establishing characteristic project of treatment and raising curative effect and life quantity.
METHOD:The expression of COX-2 protein was examined in 30 radiosensitive and 30 radioresistant poorly differentiated NPC by immunohistochemical staining (SP method) before radiotherapy. The relation between the expression of COX-2 and the effect of radiotherapy was analyzed.
RESULT:The positive rate of COX-2 protein expression was 61. 67% in NPC tissues, there was statistical difference( P <0. 01) of the positive rate between the 86. 67 % of 30 radioresistant and 36. 67 % of radiosensitive NPC tissues. The intensity of COX-2 protein expressions showed statistical difference( P <0. 05),too. Based on the expression of COX-2, the effect of radiotherapy, sensitivity, specificity, accuracy, positive predictive value, negative predictive value, false positive and false negative were predicted as follows: 86. 67Y, 63. 33% ,75. 00%, 70. 27% ,82. 61% ,36. 67% and 13. 33 , respectively.
CONCLUSION:COX-2 expression may serve as a marker in predicting the response to radiotherapy in NPC. According to the expression of COX-2, the sound treatment scheme can be selected.
