Expression and significance of nuclear factor-kappa B ligand and correlation factor in the tissue of otitis media with cholesteatoma.
- Author:
Ming XIA
1
;
Shouling DING
;
Hanbing ZHANG
;
Fang LIU
;
Haiying YIN
;
Anting XU
Author Information
1. Department of Otorhinolaryngology-Head and Neck Surgery, Qilu Hospital , Shandong University, Jinan, 250012 , China. xm_sduniversity@yahoo.com
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Case-Control Studies;
Cholesteatoma, Middle Ear;
metabolism;
pathology;
Ear Ossicles;
pathology;
Female;
Humans;
Male;
Middle Aged;
Osteoprotegerin;
metabolism;
RANK Ligand;
metabolism;
Receptor Activator of Nuclear Factor-kappa B;
metabolism;
Young Adult
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2007;21(7):315-317
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the expressions of nuclear factor-kappa B ligand (RANKL), receptor activator of nuclear factor-kappa B(RANK)and osteoprotegerin (OPG) and the relation of RANKL with bone- erosion in human cholesteatoma tissue.
METHOD:Thirty cholesteatoma and twenty normal auditory canal skin specimens were investigated. The expressions of RANKL, RANK and OPG were examined by immunohistochemistry.
RESULT:The overexpressions of the cytokine RANKL and RANK were found in infiltrated lymphocytes in the cholesteatoma tissue comparing with normal external meatal skin( t = 7. 758,6. 482, P <0. 05); While, the expression of OPG was significantly higher in cholesteatoma tissue comparing with normal external meatal skin. the OPG/ RANKL was decreased in cholesteatoma tissue comparing with normal external meatal skin( t = 8. 183, P < 0. 05).
CONCLUSION:This study revealed that the expressions level of RANKL and RANK were markedly increased in the perimatrix of cholesteatoma, which is closely related to the bone- erosion induced by cholesteatoma.
