The methods of establishing rhinogenic model of acute sinusitis in the rabbit.
- Author:
Pengju WNAG
1
;
Yin SHEN
Author Information
1. wangpju@sohu.com
- Publication Type:Journal Article
- MeSH:
Acute Disease;
Animals;
Disease Models, Animal;
Inflammation;
Rabbits;
Sinusitis
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2007;21(8):366-367
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To create a rhinogenic model of acute sinusitis in the rabbits.
METHOD:Thirty-two New Zealand white rabbits were divided into four groups: A group (nasal cavity-implanted with synthetic sponge), B group (nasal cavity-implanted with synthetic sponge and bacteria inoculation), C group (bacteria inoculation group), D group (control). The animals were examined by the methods of endoscope, histology and bacteriology after two weeks.
RESULT:The success rate of model were 60% (A group), 100% (B group) and 0% (C,D group). Both maxillary sinus and ethmoid sinus had developed inflammation.
CONCLUSION:A rhinogenic model of acute sinusitis can be created by inserting synthetic sponge instilled with pathogenic bacteria into nasal cavity. This is a simple method and has the potential to be valuable to study on FESS.
