The expression and significance of adaptin-2 in mice cochlea.
- Author:
Xiang GU
;
Rui SONG
;
Zhiji CHEN
;
Wei YUAN
- Publication Type:Journal Article
- MeSH:
Adaptor Protein Complex alpha Subunits;
metabolism;
Animals;
Cochlea;
Hair Cells, Auditory;
Hair Cells, Auditory, Inner;
metabolism;
Mice;
Microscopy, Confocal;
Synapses
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2015;29(1):83-85
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the expression of adaptin-2(AP-2) in mice cochlea and to discuss the probable role in the endocytosis of hair cells.
METHOD:Laser scanning confocal microscopy and immune-fluroscence histochemistry were performed in this study.
RESULT:In mature mice cochlea, the immunoreactivity for AP-2 was found in the inner hair cells cytoplasm. This protein mainly expressed in the hair cells basal part and nearby the ribbon synapse.
CONCLUSION:AP-2 protein mainly expressed in the hair cells synaptic activity zone , which suggested that AP-2 could play an important role in the synaptic vesicle endocytosis. This finding built the foundation for the further research involved in the physiological and pathological role of AP-2.
