Pharmacologic Effects of Atropine Penalization in Amblyopic Eyes.
10.3341/jkos.2014.55.4.590
- Author:
Sun Ho PARK
1
;
Sae Mi PARK
;
A Ran CHO
;
Song Hee PARK
Author Information
1. Department of Ophthalmology, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Korea. scheye@hosp.sch.ac.kr
- Publication Type:Original Article
- Keywords:
Amblyopia;
Atropine penalization treatment;
Weekend atropine
- MeSH:
Amblyopia;
Atropine*;
Child;
Follow-Up Studies;
Humans;
Pupil;
Visual Acuity
- From:Journal of the Korean Ophthalmological Society
2014;55(4):590-595
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To analyze the pharmacologic effect of atropine penalization in amblyopic eyes. METHODS: Distant and near visual acuity, near point of accommodation (NPA), and pupil size were measured in the sound eye of 40 children with amblyopia before and after receiving atropine sulfate 1% solution. Amblyopic children were divided into 2 groups according to the time of follow-up visit: 4-days and 7-days after injection; the same tests were performed on all the scheduled follow-up visits. This study included a control group of 20 normal children who received the same test on the initial visit and the scheduled follow-up visits. RESULTS: Visual acuity of the sound eye at distance showed greater decreases in children with 4-day follow-up visits compared with 7-day visits in the amblyopic group (p = 0.24). There was no significant difference in near visual acuity between the amblyopic group and the normal control group by follow-up interval (p = 0.98, p = 0.75). Near point of accommodation significantly increased in the 4-day visit group in both the amblyopic and the normal control groups (p = 0.04 and p = 0.03, respectively), Pupil size was significantly maintained in the 4-day visit, amblyopic group (p = 0.01). CONCLUSIONS: Atropine effectively decreased the vision of the sound eye in amblyopic children. However, to maintain the pharmacologic effect, two separate atropine instillations per week (on a weekday and the weekend) should be considered as a treatment for amblyopia.
