The correlation between stanniocalcin 2 expression and prognosis in laryngeal squamous cell cancer.
- Author:
Cunliang ZHANG
;
Zhong GUAN
;
Jieren PENG
- Publication Type:Journal Article
- MeSH:
Carcinoma, Squamous Cell;
metabolism;
mortality;
Glycoproteins;
biosynthesis;
Head and Neck Neoplasms;
metabolism;
mortality;
Humans;
Intercellular Signaling Peptides and Proteins;
biosynthesis;
Laryngeal Neoplasms;
metabolism;
mortality;
Prognosis;
Squamous Cell Carcinoma of Head and Neck;
Survival Analysis;
Survival Rate
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2015;29(2):102-107
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:In this study, we have detected the expression of STC2 protein in laryngeal cancer and The safe incisal margin by immunohistochemical staining, to evaluate its correlation with clinical features and the prognosis value in laryngeal squamous cell cancer.
METHOD:Eighty-one paraffin-embedd specimens of patients who underwent surgery for laryngeal cancer were collected. Clinical data, including date of birth, gender, tumor subsite, tumor stage, RT, and survival status have been recorded. The samples including laryngeal cancer tissues and the safe incisal margin were analyzed for the expression of STC2 protein by immunohistochemical staining. We analyzed the correlations with STC2 expression level and clinical data with software SPSS 18. 0.
RESULT:(1)fifty-six cases in 81 cases (69. 1 %) are positive. In 30 cases of the safe incisal margin tissues, STC2 is not expressed, which shows statistically significant differences between the two groups (P<0. 05). (2)Overexpression of STC2 in laryngeal cancer were correlated with the tumor clinical stage and N stage, T stage, tumor site location and histological grade (P<0. 05), but not with genderor age (P> 0. 05). (3)The result showed that the 3-year survival rate is 74. 1%, according to the survival analysis by STC2, STC2 positive group has poorer outcome versus the negative group. (4)The clinical stage displayed the independent value in predicting the tumor prognosis of laryngeal cancer (P<0. 05), not the expression level of STC2.
CONCLUSION:Overexpression of STC2 in laryngeal cancer patients is correlated with poor outcome, which means STC2 positive group has poorer prognosis than the STC2 negative group.
