Clinical study of the combination therapy with intranasal antihistamine and nasal corticosteroids in the treatment of nasal obstruction of persistent non-allergic rhinitis.
- Author:
Limin GUO
;
Xicai SUN
;
Juanmei YANG
;
Juan LIU
;
Dehui WANG
- Publication Type:Journal Article
- MeSH:
Administration, Intranasal;
Adrenal Cortex Hormones;
therapeutic use;
Drug Therapy, Combination;
Histamine H1 Antagonists;
therapeutic use;
Humans;
Nasal Obstruction;
Phthalazines;
therapeutic use;
Rhinitis;
drug therapy
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2015;29(3):243-251
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To determine if greater efficacy could be achieved with the intranasal antihistamine azelastine and the intranasal corticosteroid fluticasone propionate used concurrently in the treatment of nasal obstruction of persistent non-allergic rhinitis.
METHOD:A total of 162 persistent non-allergic rhinitis cases with moderate to severe nasal obstruction were randomized to treatment with the following: the combination therapy or nasal corticosteroids monotherapy. Efficacy was assessed by change from baseline in nasal obstruction score at week 2 and week 6 visits. The perceptions of global treatment satisfaction(convenience, side effects, cost and effectiveness) in both groups were analyzed.
RESULT:In both groups, the nasal obstruction score assessment descended significantly at week 2 and week 6 visits versus at baseline (all P < 0.01). At week 2 and week 6 visits, the nasal obstruction score in the combination therapy groups were significantly improved than that in nasal corticosteroids monotherapy groups (all P < 0.01). The perceptions of global treatment satisfaction in the combination therapy groups were significantly better (P < 0.05).
CONCLUSION:Azelastine nasal spray and intranasal corticosteroid in combination may provide a substantial therapeutic benefit for patients with persistent non-allergic rhinitis, especially nasal obstruction. The combination therapy was well tolerated and safety.
