An empirical study of treating chronic sinusitis with low dose Roxithromycin.
- Author:
Yan SONG
1
;
Weiliang BAI
;
Wenyue JI
Author Information
1. Department of Otolaryngology, Shengjing Hospital, China Medical University, Shenyang, 110004, China. songyl@sj-hospital.org
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Anti-Bacterial Agents;
administration & dosage;
therapeutic use;
Apoptosis;
Child;
Chronic Disease;
Female;
Humans;
Male;
Middle Aged;
Nasal Polyps;
complications;
drug therapy;
Roxithromycin;
administration & dosage;
therapeutic use;
Sinusitis;
complications;
drug therapy;
Young Adult
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2009;23(8):357-363
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:Observe the therapeutic effect of low dose Roxithromycin in treating chronic sinusitis and further discuss the mechanism of Roxithromycin facile endothelial cell apoptosis.
METHOD:All 47 patients who suffer chronic sinusitis at out-patient clinic from 2006. 10 to 2008. 03 were administered low dose Roxithromycin. Follow up all the patients and get polypi at 3-month and 6-month. AO/EB was employed to detect the apoptosis of endothelial cell.
RESULT:At 3-month and 6-month the improvement of ventilation are 37.25 +/- 12.21, 63.15 +/- 22.78; Decrease of nasal discharge are 42.12 +/- 13.56, 74.45 +/- 28.79; alleviation of headache are 18.98 +/- 7. 66, 34.47 +/- 14.11; Improvement of olfactory are 21.23 +/- 8.41, 38.18 +/- 16.54; Apoptotic index are (39.54 +/- 6.86)% and (62.34 +/- 8.67)%, which are significantly different (P<0.05).
CONCLUSION:Low dose Roxithromycin has good long term curative effect in treating chronic sinusitis. Low dose Roxithromycin can greatly urge the apoptosis of endothelial cell.
