Expression and significance of VEGF-C and VEGF-D in differentiated thyroid carcinoma.
- Author:
Huajie LUO
1
;
Jiping LI
;
Tengfei YANG
;
Jiadong WANG
Author Information
1. Department of Otolaryngology-Head and Neck Surgery, Renji Hospital, Shanghai Jiaotong University, Shanghai, 200001, China. luohuajie2000@yahoo.com.cn
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Carcinoma, Papillary;
metabolism;
pathology;
Female;
Humans;
Lymphatic Metastasis;
Male;
Middle Aged;
Thyroid Neoplasms;
metabolism;
pathology;
Vascular Endothelial Growth Factor C;
metabolism;
Vascular Endothelial Growth Factor D;
biosynthesis;
Young Adult
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2009;23(12):531-534
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:VEGF-C,D are known to be capable of inducing proliferation of lymphatic endothelia cell and development of lymphatic vessels, so we investigated the expression of VEGF-C,D in the differentiated thyroid carcinoma tissues microarray in order to understand the significance mechanism of cervix lymphatic metastasis of thyroid cancer.
METHOD:A tissue microarray containing 71 specimens was constructed, including normal thyroid tissues, thyroid adenoma, papillary thyroid carcinoma with and without lymphatic metastasis, follicular thyroid carcinoma. VEGF-C, D protein expression was detected with immunohistochemistry.
RESULT:The expression of VEGF-C,D were not observed in normal thyroid tissues and adenoma tissues. The expression of VEGF-C,D in papillary thyroid carcinoma was significantly higher than those in follicular thyroid carcinoma (P < 0.05) and adeno ma tissues (P < 0.01). The expression of VEGF-C,D in papillary thyroid carcinoma with lymphatic metastasis was significantly higher than those in papillary thyroid carcinoma without lymphatic metastasis (P < 0.05).
CONCLUSION:By inducing proliferation of lymphatic endothelia cell and development of lymphatic vessels, VEGF-C,D contributed to lymphatic metastasis of papillary thyroid carcinoma.
