The expression of oncogene AKT2 in laryngeal squamous cell carcinoma and its clinical significance.
- Author:
Yingchao CHEN
1
;
Yuanping HE
;
Shaorong ZHANG
;
Lixiang LI
;
Xinhua ZHU
;
Yuehui LIU
Author Information
1. Department of Otolaryngology Head and Neck Surgery, the Central Hospital of Xiaogan, Xiaogan, 432100, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Carcinoma, Squamous Cell;
metabolism;
pathology;
Female;
Humans;
Laryngeal Mucosa;
metabolism;
pathology;
Laryngeal Neoplasms;
metabolism;
pathology;
Lymphatic Metastasis;
Male;
Middle Aged;
Neoplasm Staging;
Prognosis;
Proto-Oncogene Proteins c-akt;
metabolism
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2009;23(12):539-545
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the expression and clinical significance of oncogene AKT2 in laryngeal squamous cell carcinoma (LSCC).
METHOD:The expression of AKT2 protein was measured with immunohistochemistry (Elivision two steps) in 60 cases of LSCC tissue, 28 cases of peri-cancer tissue and 16 cases of normal laryngeal epithelium, the relationship between AKT2 expression and clinical pathologic factors in LSCC was also analyzed.
RESULT:The positive rates of AKT2 protein expression in LSCC and peri-cancer tissue were 56.7% (34/60), 14.3% (4/28) respectively. There was no expression of AKT2 in normal laryngeal epithelium. The positive rate of AKT2 protein expression in LSCC was significantly higher than that in peri-cancer tissue and normal laryngeal epithelium (P < 0.05, respectively). The positive rate of AKT2 was correlated with tumor site, lymph node metastasis and clinical stage of LSCC (P < 0.05, respectively), but wasn't correlated with patient's age, sex, and T stage (P > 0.05, respectively).
CONCLUSION:AKT2 might play an important role in the tumorigenesis and development of LSCC, and it was suggested that AKT2 could be a useful marker for predicting tumorigenesis, invasion and metastasis potential of LSCC.
