Studies on the effects of Qi-boosting toxin-resolving decoction on proliferation of nasopharyngeal carcinoma cell.
- Author:
Binya HU
1
;
Daofa TIAN
;
Yingchun HE
Author Information
1. Department of Otolaryngology, Hunan Children's Hospital, Changsha, 410007, China. zhizi628@126.com
- Publication Type:Journal Article
- MeSH:
Animals;
Cell Line, Tumor;
Cell Proliferation;
drug effects;
Drugs, Chinese Herbal;
pharmacology;
Humans;
Medicine, Chinese Traditional;
Nasopharyngeal Neoplasms;
Rats;
Rats, Sprague-Dawley;
Serum
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2009;23(12):558-560
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effect of several traditional Chinese medicine formula therapies on proliferation of nasopharyngeal carcinoma cell line HNE1.
METHOD:The inhibition effect of medicine serums of Qi-Boosting Toxin-Resolving granule on proliferation of NPC cell line HNE1 in vitro was observed by MTT assay.
RESULT:The rates of survival cells in Qi-Boosting Toxin-Resolving decoction group and Toxin-Resolving group were the lowest after 48 hours treatment, while Qi-Boosting group, yin-nourishing group, residual-component group medicine serums had the most obvious effects on the rates of survival cells at 72 hours. The inhibition ratio of 15% Qi-Boosting Toxin-Resolving granule medicine serums was 67.68%.
CONCLUSION:The result of MTT assay showed that cell proliferation was significantly inhibited by Qi-Boosting Toxin-Resolving granule and its separate composes medicine serums. Qi-Boosting Toxin-Resolving granule had the most significantly specific effects. The effects were correlated with serum concentration and treatment time of Qi-Boosting Toxin-Resolving granule and its separate composes medicine.
