Expression and significance of VCAM-1 in subjects with allergic inflammation of respiratory tract.
- Author:
Yuanyuan WANG
1
;
Minghui ZHOU
;
Weihua LOU
Author Information
1. Department of Otorhinolaryngology, Huaihe Hospital of Henan University, Kaifeng, 475000, China. zmh0334@yahoo.com.cn
- Publication Type:Journal Article
- MeSH:
Adult;
Asthma;
complications;
metabolism;
Female;
Humans;
Inflammation;
Male;
Middle Aged;
Nasal Mucosa;
metabolism;
Rhinitis;
complications;
metabolism;
Vascular Cell Adhesion Molecule-1;
metabolism
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2009;23(11):506-512
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the expression and significance of vascular cell adhesion molecule-1 (VCAM-1) in subjects with allergic inflammation of respiratory tract.
METHOD:Thirty-nine subjects with allergic rhinitis and asthma (allergic rhinitis and asthma group) and twenty-one subjects with only allergic rhinitis (allergic rhinitis group) were divided into two group. Bronchial and nasal biopsy specimens were taken and were stained with HE. The expression of VCAM-1 in nasal and bronchial mucosa was detected by immunohistochemistry technique.
RESULT:The amounts of eosinophils within bronchial mucosa of allergic rhinitis and asthma group were significantly higher than that of allergic rhinitis group (t=12.81, P<0.01). The difference of VCAM-1 expression between allergic rhinitis group and allergic rhinitis and asthma group was not statistically significant . The amounts of VCAM-1 positive cell in bronchial mucosa of allergic rhinitis and asthma group were significantly higher than that of allergic rhinitis group (t=9.43, P<0.01). The number of VCAM-1 positive cells in bronchial mucosa was significantly positively correlated with the number of eosinophils in bronchial mucosa of allergic rhinitis and asthma group (r=0.783, P<0.01).
CONCLUSION:This study shows that upregulation of VCAM results in generalized airway inflammation in patients with allergic rhinitis.
