The relationship between the expression of EGFR NF-kappaB and radiosensitivity in human nasopharyngeal carcinoma.
- Author:
Chunni YANG
1
;
Yibing YANG
;
Yiqin AI
Author Information
1. Department of Otolaryngology, the First Affiliated Hospital of Kunming Medical College, Kunming.
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
ErbB Receptors;
metabolism;
Female;
Humans;
Male;
Middle Aged;
NF-kappa B;
metabolism;
Nasopharyngeal Neoplasms;
metabolism;
pathology;
radiotherapy;
Radiation Tolerance;
Young Adult
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2009;23(15):678-681
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To detect the expression of EGFR and NF-kappaB and the relationship between the two factors and radiosensitivity in human nasopharyngeal carcinoma.
METHOD:The expression of EGFR and NF-kappaB were detected with immunohistochemical staining SP methods in forty-one patients. The radiotherapy effect was assessed by follow up visit and clinical judgement. All of the forty-one patients were divided into three groups: the complete response group, the partial response (or the stable disease) group and the progressive disease group.
RESULT:The expression of EGFR and NF-kappaB were detected in human nasopharyngeal carcinoma tissues, which were not in normal ones. EGFR and NF-kappaB were significant difference of the radiosensitivity in nasopharyngeal carcinoma tissues (P<0.05). The expression of EGFR and NF-kappaB in the complete response-group and the partial response (or the stable disease)-group were lower than the progressive disease-group (P<0.05), and there was no significant difference between the complete response-group and the partial response (or the stable disease)-group (P>0.05). The two factors' expression had negative correlation with radiosensitivity.
CONCLUSION:EGFR and NF-kappaB, as important targets, could predict the radiosensitivity of NPC, which could be helpful for targeting treatment and promote the effect of radiotherapy of NPC.
