Preventive effects of pueraria on presbycusis in rats.
- Author:
Wangyan CHEN
1
;
Qi YAO
;
Weihong LIU
;
Bibo ZHANG
;
Ying WANG
;
Bo LIU
Author Information
1. Department of Otorhinolaryngology, Chinese and Western Medicine Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430000, China. meniere@163.com
- Publication Type:Journal Article
- MeSH:
Aging;
Animals;
Auditory Threshold;
Evoked Potentials, Auditory, Brain Stem;
Hemorheology;
Phytotherapy;
Presbycusis;
drug therapy;
Pueraria;
chemistry;
Rats;
Rats, Wistar
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2009;23(15):703-705
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the preventive effects of Pueraria on presbycusis in rats.
METHOD:Thirty-two 24-26 month old Wistar rats were randomly divided into four groups, and were treated with different dosages of Pueraria (1, 2, 4, 0 g x kg(-1) x d(-1)) separately for 4 weeks. Auditory brainstem response (ABR) was used to detect the change of hearing threshold of rats. Hemorheological items of rats were checked in each group.
RESULT:Compared with control group, the hearing threshold and hemorheological items of rats was significantly improved after treated with Pueraria (P<0.05). In addition, 2 g/(kg x d) was found to be the best dosage of Pueraria for rats, which can achieve ideal effect with minimum side effect.
CONCLUSION:Pueraria could improve tiny circulation, has good preventive effect on presbycusis of rats.
