Expression of thymic stromal lymphopoietin in nasal mucosa of a mouse model with allergic rhinitis.
- Author:
Meili XU
1
;
Yongqing GUO
Author Information
1. Department of ICU, Zhongshan Hospital, Xiamen University, Xiamen, 361004, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Cytokines;
metabolism;
Disease Models, Animal;
Female;
Mice;
Mice, Inbred BALB C;
Nasal Mucosa;
metabolism;
Ovalbumin;
biosynthesis;
Rhinitis, Allergic, Perennial;
metabolism
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2009;23(17):794-799
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the expression of thymic stromal lymphopoietin (TSLP) in the nasal mucosa of mouse with allergic rhinitis.
METHOD:Twenty wide type BALB/c mouse were divided into 2 groups randomly. Two groups were included, allergic rhinitis group (group A) and control group (group B). The mouse model of allergic rhinitis was established by ovalbumin (OVA) sensitization and challenge. The expressions of TSLP in the nasal mucosa was determined by realtime quantitative PCR and immunohistochemical method.
RESULT:The expression of TSLP in the nasal mucosa of group A was significantly higher than that in group B (P<0.01).
CONCLUSION:TSLP plays a role in the mouse model of allergic rhinitis.
