The effect of the expression and influence of MMP-9 on prognosis of nasal polyps.
- Author:
Jiangbo CHEN
1
;
Tiansheng WANG
;
Hong SUN
Author Information
1. Department of Otolaryngology, the Third Xiangya Hospital, Central South University, Chan-gsha, 410013, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Case-Control Studies;
Eosinophils;
metabolism;
Female;
Humans;
Male;
Matrix Metalloproteinase 9;
metabolism;
Nasal Mucosa;
metabolism;
Nasal Polyps;
diagnosis;
metabolism;
pathology;
Prognosis;
Recurrence
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2009;23(18):840-845
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the expression of MMP-9 and eosinophils in nasal polyps and its influence on the prognosis.
METHOD:Study the expression of MMP-9 and EOS on the tissue of nasal polyps of patients who were cured or recurrent and normal nasal mucosa (NM) by immunohistochemistry and HE staining.
RESULT:In the patients of recurrent group (Group B), the expression of MMP-9 was much stronger than that of good prognosis group (Group A) and NM. The MMP-9 was stronger in the eosinophil nasal polyps than that of non-eosinophil groups. The percentage of EOS in Group A was 16.67%, while 62.50% in the Group B.
CONCLUSION:The stronger expression of MMP-9 on Group B and eosinophil group indicated that MMP-9 might affect the prognosis of nasal polyps through inducing the number of EOS in the mucosa. MMP-9 may be one of the risk factors for the relapse of nasal polyps.
