Expression of Survivin and Bcl-2 in sinonasal inverted papilloma.
- Author:
Jinhui LIANG
1
;
Shan GAO
;
Jian ZHANG
;
Hongmin AO
;
Xianlin WEI
;
Hailin LUO
Author Information
1. Department of Otolaryngology, Central Hospital of Hanzhong, Hanzhong, 723000, China. jackydoctor@sohu.com
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Carcinoma, Squamous Cell;
metabolism;
pathology;
Female;
Humans;
Inhibitor of Apoptosis Proteins;
metabolism;
Male;
Middle Aged;
Nose Neoplasms;
metabolism;
pathology;
Papilloma, Inverted;
metabolism;
pathology;
Paranasal Sinus Neoplasms;
metabolism;
pathology;
Proto-Oncogene Proteins c-bcl-2;
metabolism;
Survivin;
Young Adult
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2009;23(20):933-935
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the expression of Survivin and its relationship with the expression of Bcl-2 in sinonasal inverted papilloma (SNIP).
METHOD:Immunohistochemical method was used to determine the expression of Survivin and Bcl-2 in 30 cases of SNIP, 10 cases of sinonasal squamous cell carcinoma (SCC) and 10 cases of normal inferior concha tissues.
RESULT:Survivin was expressed in 22 of 30 (73.3%) cases of SNIP, 8 of 10 (80.0%) cases of SCC and not expressed in 10 (0%) cases of normal inferior concha tissues. Expression of Survivin was significantly higher in SNIP and SCC than in normal tissues. Bcl-2 was expressed in 9 of 10 (90.0%) cases of SCC and 2 of 10 (20.0%) cases of normal inferior concha tissues. Expression of Bcl-2 was significantly higher in SCC than in normal tissues. Bcl-2 was expressed in 14 of 30 (46.7%) cases of SNIP, higher than normal tissues. Expression of Bcl-2 was positively related to expression of Survivin.
CONCLUSION:Survivin may play an important role in the pathway of progression of SNIP and SCC. It may be identified as a new therapeutic target. Bcl-2 may play a synergic role with Survivin in progression of SNIP.
