The treatment and clinical therapeutic effect analysis in 59 cases of advanced supraglottic laryngeal squamous cell carcinoma.
- Author:
Qimin LAI
;
Hao LI
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Carcinoma, Squamous Cell;
pathology;
radiotherapy;
surgery;
Combined Modality Therapy;
Female;
Glottis;
pathology;
Head and Neck Neoplasms;
pathology;
radiotherapy;
surgery;
Humans;
Laryngeal Neoplasms;
pathology;
radiotherapy;
surgery;
Laryngectomy;
Male;
Middle Aged;
Neck Dissection;
Squamous Cell Carcinoma of Head and Neck;
Survival Rate;
Treatment Outcome
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2013;27(24):1366-1369
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To compare the therapeutic effect of postoperative radiotherapy with surgery alone in advanced supraglottic laryngeal squamous cell carcinoma (LSCC).
METHOD:According to the treatment methods, 59 patients with advanced supraglottic LSCC were divided into surgery plus radiotherapy group (S+R group) (33 cases) and surgical group (S group) (26 cases). In S+R group, total laryngectomy was performed on 27 patients and partial laryngectomy on 6 patients, 27 of whom underwent lateral neck dissections; while in S group, total laryngectomy was performed on 23 patients and partial laryngectomy on 3 patients, 24 of whom underwent lateral neck dissections.
RESULT:The 3-year overall survival rate of S+R and S group were 62.6% and 62.6% respectively, and the 5-year overall survival rate of S+R and S group were 43.8% and 40.5% respectively. But there was no statistically significant difference of survival rate between two groups by Log-rank test (P > 0.05). In S+R group, recurrence happened in 5 cases and the recurrent rate was 15.1%; in S group, recurrence happened in 10 patients and the recurrent rate was 38.5%, statistically significant difference was found between the two recurrent rates (P < 0.05).
CONCLUSION:Surgery combined with postoperative radiotherapy could not improve the 3-year-or 5-year overall survival rate, but could significantly reduced tumor recurrence rate.
