Clinical analysis of sudden deafness after radiotherapy and chemotherapy in nasopharyngeal carcinoma patients.
- Author:
Liangzhong YAO
;
Junjie LIU
;
Zhiling PAN
;
Xiangning YANG
;
Yanli ZHU
- Publication Type:Journal Article
- MeSH:
Antineoplastic Agents;
adverse effects;
Carcinoma;
Dizziness;
etiology;
therapy;
Hearing Loss, High-Frequency;
etiology;
therapy;
Hearing Loss, Sudden;
etiology;
therapy;
Hearing Tests;
Humans;
Hyperbaric Oxygenation;
Nasopharyngeal Carcinoma;
Nasopharyngeal Neoplasms;
drug therapy;
radiotherapy;
Radiotherapy;
adverse effects;
Retrospective Studies;
Tinnitus;
etiology;
therapy;
Vertigo;
etiology;
therapy
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2014;29(8):733-735
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the clinical features and therapeutic effects of sudden deafness after radiotherapy combined with chemotherapy in nasopharyngeal carcinoma patients.
METHOD:Clinical data of 42 nasopharyngeal carcinoma patients suffered from sudden deafness after radiotherapy combined with chemotherapy were analyzed retrospectively. Among the 42 patients, 2 showed moderate deafness, 4 presented excessive deafness, 30 suffered from severe deafness, and 6 exhibited profound deafness. The audiogram pattern of 33 patients met with the type of high tone frequencies hearing loss, and that of the rest 9 cases showed hearing loss at all frequencies. All patients received medical therapy combined with hyperbaric oxygen therapy.
RESULT:Of all the cases with hearing loss, 2 were cured, 2 showed excellent recovery, 9 came out partial recovery, and 29 showed no response to the treatment. The total effective rate was 30.95%. For the accompanied symptoms, none of the 30 cases of tinnitus were relieved, 3 out of 10 cases of aural fullness were cured, and the 5 cases of dizziness or vertigo were all improved.
CONCLUSION:The sudden deafness after radiotherapy combined with chemotherapy in patients with nasopharyngeal carcinoma is closely related to radiotherapy. The hearing loss is serious, and the therapeutic effects are not satisfactory.
