A Case of Pure Red Cell Aplasia Associated with Angioimmunoblastic T-cell Lymphoma.
- Author:
Jung Hye CHOI
1
;
Young Ha OH
;
Ile Kyu PARK
Author Information
1. Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea. jhcmd@hanyang.ac.kr
- Publication Type:Case Report
- Keywords:
Red-cell aplasia;
Pure;
Lymphoma;
T-cell
- MeSH:
Abdomen;
Adult;
Anemia;
Biopsy;
Bone Marrow;
Coombs Test;
Female;
Hematologic Diseases;
Hemoglobins;
Humans;
Lymphocytes;
Lymphoma;
Lymphoma, T-Cell;
Red-Cell Aplasia, Pure;
Reticulocyte Count;
T-Lymphocytes;
Thrombocytopenia
- From:Cancer Research and Treatment
2010;42(2):115-117
- CountryRepublic of Korea
- Language:English
-
Abstract:
Pure red cell aplasia is a bone marrow failure characterized by a progressive normocytic anemia and reticulocytopenia without leucopenia and thrombocytopenia. It is associated with various hematologic diseases. However, pure red cell aplasia with angioimmunoblastic T cell lymphoma has rarely been reported. Here we describe a 43-year-old woman with pure red cell aplasia associated with angioimmunoblastic T-cell lymphoma. She had severe anemia (hemoglobin 6.9 g/dL) and a low reticulocyte count (0.2%). Direct and indirect Coombs' tests were positive. A CT scan of the abdomen revealed marked hepatosplenomegaly and small multiple lymphadenopathies. A bone marrow biopsy revealed focal infiltration of abnormal lymphoid cells and absence of red cell precursors. Splenic biopsy was compatible with angioimmunoblastic T-cell lymphoma. Ultimately, diagnosis of pure red cell aplasia associated with angioimmunoblastic T-cell lymphoma was made. After initiating CHOP therapy, the patient achieved complete remission, which was accompanied, shortly thereafter, by a rise in hemoglobin levels which finally returned to normal.
