Detect myelin structure in acoustic tumor.
- Author:
Yan WANG
1
;
Haiyang JIANG
;
He YU
;
Chao GUAN
;
Xuejun JIANG
Author Information
1. Department of Otolaryngology, the First Affiliated Hospital of China Medical University, Shenyang, 110001, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Microscopy, Electron;
Myelin Sheath;
pathology;
ultrastructure;
Neuroma, Acoustic;
pathology;
Schwann Cells;
pathology
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2011;25(4):169-175
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:By detecting the myelin structure in acoustic tumor tissues, the cell origin and state of acoustic tumor tissues were investigated.
METHOD:Immunofluorescence labeling, immunoblot analysis and electron microscopic study were performed to identify myelin structure and myelin protein in acoustic tumor tissues.
RESULT:In this work, we found some early stage of myelin forming in acoustic tumor tissues, but there were no axon nor compact myelin formed and the myelin basic protein whose expression indicates the beginning of myelination was negative detected. We also found that the cell of acoustic tumor express p75,a marker for immature Schwann cells and mature non-myelin-forming Schwann cells.
CONCLUSION:The date shown in this experiment indicates that the cell of acoustic tumor is in a remyelinating state.
