Association of IL-1beta gene -31T/C polymorphism with chronic rhinosinusitis.
- Author:
Nijun CHEN
1
;
Peihua NI
;
Changping CAI
;
Shili WANG
Author Information
1. Department of Otolaryngology, Ruijin Hospital, Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Case-Control Studies;
Chronic Disease;
Female;
Gene Frequency;
Genotype;
Humans;
Interleukin-1beta;
genetics;
Male;
Middle Aged;
Polymorphism, Single Nucleotide;
Sinusitis;
genetics
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2011;25(5):197-200
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the relationship between polymorphism of IL-1beta gene 31T/C and chronic rhinosinusitis.
METHOD:One hundred and twenty-three patients with chronic rhinosinusitis and 239 healthy controls were collected to determine the genotypes by polymerase chain reaction-restriction fragment length polymorphism.
RESULT:There was significant difference in genotype and allelic frequencies between the CRS and control group (P < 0.05). -31CC genotype was an independent risk factor with CRS (P < 0.05, OR = 1.639). There was no significant difference in TIgE and ECP among these genotypes (P > 0.05).
CONCLUSION:IL-1beta gene 31CC genotype may be an independent risk factor with chronic rhinosinusitis.
