Latent membrane protein-1 of EB virus and the phenotype of epithelial-mesenchymal transition and cervical lymph node metastasis in nasopharyngeal carcinoma.
- Author:
Lihua YUE
1
;
Zhiyi JIANG
;
Wanxin WU
;
Yanping ZHANG
;
Peng YIN
;
Yajun ZHANG
;
Cheng SHENG
;
Guobiao WEI
;
Xiang LI
;
Kai LING
Author Information
1. Department of Otorhinolaryngology, the First Affiliated Hospital of Jiaxing College, Jiaxing, 314000, China. yuelihuazj@hotmail.com
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Cadherins;
metabolism;
Epithelial-Mesenchymal Transition;
Female;
Herpesvirus 4, Human;
metabolism;
Humans;
Lymphatic Metastasis;
Male;
Middle Aged;
Nasopharyngeal Neoplasms;
pathology;
virology;
Neck;
pathology;
Nuclear Proteins;
metabolism;
STAT3 Transcription Factor;
metabolism;
Twist-Related Protein 1;
metabolism;
Vimentin;
metabolism;
Viral Matrix Proteins;
metabolism;
Young Adult
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2011;25(6):270-273
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the relation of EB virus latent membrane protein-1 (LMP-1) and the phenotype of epithelial-mesenchymal transition (EMT) and cervical lymph node metastasis in nasopharyngeal carcinoma.
METHOD:Based on histopathology and MRI imaging, nasopharyngeal biopsy tissues from 88 patients with nasopharyngeal carcinoma were divided into 3 groups: pathologic metastasis (18), MRI metastasis(40) and without metastasis (30). The expressions of LMP-1, STAT3, Twist, E-Cadherin and Vimentin were examined immunohistochemically in biopsy tissues.
RESULT:LMP-1 expression was found in 35 of 88 biopsy tissues with a positive rate of 38.7%. The positive rates of LMP-1 in groups of pathologic metastasis, MRI metastasis and without metastasis were 38.9% (7/18), 47.5% (19/40) and 30.0% (9/30), respectively, and significant difference were not found among three groups. The expression of LMP-1 was positively correlated to both expressions of Twist and Vimentin (r = 0.276 and 0.282, are P < 0.01), but not to both expressions of STAT3 and E-Cadherin. The positive expressions or abnormal expression of STAT3, Twist, Vimentin and E-Cadherin were found in 57 of 88 (64.8%), 48 of 88 (54.5%), 22 of 88 (20.0%)and 53 of 88 (60.2%), respectively. Significant differences in the expression of STAT3, Twist, Vimentin and E-Cadherin were all found among groups of pathologic metastasis, MRI metastasis and without metastasis, respectively (are P < 0.05). The expression of STAT3 was positively correlated to both expressions of Twist and Vimentin (r = 0.712 and 0.316, P < 0.01).
CONCLUSION:EMT plays important role in cervical lymph node metastasis in nasopharyngeal carcinoma. LMP-1 may be only as one of upstream factors associated with the EMT, but not the decisive factor for cervical lymph node metastasis.
