Content of CD4+ CD25+ regulatory T cells in peripheral blood lymphocytes in patients with allergic rhinitis.
- Author:
Shaoqing YU
1
;
Yingjian CHEN
;
Jie ZHANG
;
Zhiqiang YAN
;
Ruxin ZHANG
Author Information
1. Department of Otolaryngology, Huadong Hospital, Fudan University, Shanghai, 200040, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Case-Control Studies;
Female;
Flow Cytometry;
Humans;
Interleukin-2 Receptor alpha Subunit;
immunology;
metabolism;
Male;
Middle Aged;
Rhinitis, Allergic, Perennial;
blood;
immunology;
T-Lymphocytes, Regulatory;
immunology;
metabolism;
Young Adult
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2011;25(8):354-359
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the change of CD4- CD25 regulatory T cells (Tregs) of peripheral blood in allergic rhinitis (AR) patients.
METHOD:T lymphocytes of twenty AR patients and eight healthy subjects were separated and the flow cytometry was used to measure the percentage of CD4+ CD25+ Treg.
RESULT:Compared with control group, the percentage of Treg and CD4- CD25high Tregs of AR patients was decreased significantly (P < 0.05).
CONCLUSION:The proportion of CD4+ CD25+ Tregs decreased in AR patients conspicuously, which might be one of the pathogenesis of AR.
