The configuration of soft palate muscular phenotype in obstructive sleep apnea hypopnea syndrome.
- Author:
Siyi ZHANG
1
;
Rongming NIE
;
Pingjiang GE
;
Shaofeng LIU
;
Zhongming LU
;
Runmei GE
;
Xiaoli SHENG
;
Shaohua CHEN
Author Information
1. Department of Otolaryngology-Head and Neck Surgery, the Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, China.
- Publication Type:Journal Article
- MeSH:
Case-Control Studies;
Female;
Humans;
Male;
Middle Aged;
Muscle Fibers, Skeletal;
metabolism;
pathology;
Myosin Heavy Chains;
metabolism;
Palate, Soft;
metabolism;
pathology;
Phenotype;
Protein Isoforms;
metabolism;
RNA, Messenger;
genetics;
Sleep Apnea, Obstructive;
metabolism;
pathology
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2011;25(9):415-422
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the mRNA expression of muscle phenotype and collagen of soft palate and pathology in obstructive sleep apnea hypopnea syndrome (OSAHS).
METHOD:We used the Real-time PCR to test the mRNA expression of soft palate muscle myosin heavy chain (MyHC) phenotype and collagen in 12 OSAHS patients and 8 control patients. We also distinguished the muscle isoforms I , II with ATPase staining, then counted the numbers of isoforms muscle fiber.
RESULT:The mRNA expression of OSAHS group was more than control group in II A MyHC phenotype (P<0.01). The number of OSAHS group muscle fibre I isoform was less than control group with pH4. 3 ATPase staining (P<0.05).
CONCLUSION:Compare to control group, the enhancement happened in the mRNA expression of II A MyHC phenotype which can increase the velocity and power but de crease the enduring quality of muscle in OSAHS, and the reduce be in the I MyHC isoform of muscle fiber that can cause muscle velocity become slower and persistency become longer in OSAHS patients.
