The expression of PD4 and its significance in human laryngeal carcinoma.
- Author:
Baochun SUN
1
;
Shuwei ZHAO
;
Chengyong ZHOU
;
Dagen LIU
Author Information
1. Department of Otolaryngology, the First Affiliated Hospital of PLA General Hospital, Beijing, 100037, China. sunbaochun2009@sina.com
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Antibodies, Monoclonal;
Apoptosis Regulatory Proteins;
metabolism;
Carcinoma, Squamous Cell;
mortality;
pathology;
Female;
Humans;
Laryngeal Neoplasms;
mortality;
pathology;
Lymphatic Metastasis;
Male;
Middle Aged;
Mycoplasma Infections;
Neoplasm Staging;
Prognosis;
RNA-Binding Proteins;
metabolism
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2011;25(10):449-456
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the expression of mycoplasma monoclonal antibody PD4 in different laryngeal carcinoma tissues and their clinical significance.
METHOD:Using immunohistochemistry methods to detect 256 cases of laryngeal tissues, including 105 cases of laryngeal carcinoma tissues, 31 cases of neck metastasis lymph node tissues, 18 cases of precarcinoma tissues, 53 cases of vocal cord polyps, 20 cases of normal tissues adjacent to laryngeal carcinoma and 29 cases of normal tissues around laryngeal carcinoma.
RESULT:(1) The positive rate of PD4 was 44.76% in laryngeal carcinoma, which was much higher than that in other laryngeal tissues (P < 0.01 or P < 0.05). (2) The PD4 expression in laryngeal carcinoma was higher in the third and fourth stages than in the first and second stages, higher with cervical metastasis than those without cervical metastasis and higher in the third and second histological grade than in the first histological grade (P < 0.01 or P < 0.05). (3) To 3 and 5 years survival, PD4 positive cases had lower chance than PD4 negative cases (P < 0.01).
CONCLUSION:These results implicate that the occurrence, development and prognosis of laryngeal carcinoma may be closely related to mycoplasma infection.
